EFFICIENCY ANALYSIS OF DIFFERENT METHODS OF CHRONIC
AUTOIMMUNE URTICARIA TREATMENT

Molotilov Boris Aleksandrovich, Doctor of medical sciences, professor, head of sub-department of allergology and clinical immunology, Penza Institute of Advance Medical Studies (Penza, 8A Stasova str.), borismolotilov@yandex.ru
Aleshkin Vladimir Andrianovich, Doctor of medical sciences, professor, director of Moscow research institute of microbiology and biotechnologies named after G.N. Gabrishevsky of the Russian Federal service on customer’s rights and human wel-being surveillance (Moscow, 10 Admirala Makarova str.), info@gabrich.com
Orlova Ekaterina Aleksandrovna, Candidate of medical sciences, assistant, sub-department of allergology and clinical immunology, Penza Institute of Advance Medical Studies (Penza, 8A Stasova str.), lisaorl@yandex.ru
Novikova Lidiya Ivanovna, Candidate of medical sciences, head of the laboratory of immune preparations, Moscow research institute of microbiology and biotechnologies named after G. N. Gabrishevsky of the Russian Federal service on customer’s rights and human welbeing surveillance (Moscow, 10 Admirala Makarova str.), info@gabrich.com
Lyutov Andrey Germanovich, Doctor of medical sciences, professor, Moscow research institute of microbiology and biotechnologies named after G. N. Gabrishevsky of the Russian Federal service on customer’s rights and human wel-being surveillance (Moscow, 10 Admirala Makarova str.), info@gabrich.com

612.017.1:616.514-022.12+615.262

The have carried out an open comparative investigation of the efficiency of different methods of treatment of chronic autoimmune urticaria (Gabriglobin intravenous immunoglobulin, methotrexate, plasmapheresis, standard therapy). In the course of the analysis of the applied medicine efficiency the authors discovered that application of Gabroglobin allows to achieve the most complete control over clinical manifistation of chronic autoimmune urticarial, as well as to observe the maximum remission of the disease and a significant diameter decrease of the probe with autol-ogous serum. As opposed to methotrexate and plasmapheresis, Gabriglobin did not cause any unwanted reactions and discomfort in patients. Application of Gabriglobin intravenous immunoglobulin is the most harmless and efficient method of chronic autoimmune urticaria treatment.

autoimmune urticaria, intravenous immunoglobulin, methotrexate, plasmapheresis.

1. Goryachkina L. A. et al. Klinicheskaya allergologiya i immunologiya. Rukovodstvo dlya praktikuyushchikh vrachey [Clinical allergology and immunology for practitioners]. Moscow: Miklosh., 2009, 432 p.
2. Altrich M. L., Halsey J. F., Altman L. C. Allergy and Asthma Proceedings. 2009, no. 30 (1), pp. 28–34.
3. Nettis E. et al. The British journal of Dermatology. 2006, no. 154 (3), pp. 533–538.
4. Lam L., Whitsett C. F., McNicholl J. M. et al. The Lancet. 1993, no. 342 (8872), p. 678.
5. O’Donnell B.F., Barr R.M., Black A.K. et al. The British journal of Dermatology. 1998,no. 138(1), pp.101–106.
6. Klote M., Nelson M. P., Engler R. J. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology. 2005, no. 94, pp. 307–308.
7. Pereira C., Tavares B., Carrapatoso I. et al. European annals of allergy and clinical immunology. 2007, no. 39 (7), p. 237–242.
8. Godse K. Indian journal of dermatology, venereology and leprology. 2004, no. 70, pp. 377–387.
9. Mora P. Montero, Gonzalz Perez MdelC., V. Almeida Arvizu, J. J. Matta Campos Revista alergia Mexico [Allergy journal of Mexico]. 2004, no. 51 (5), pp. 167–172.
10. Grattan C. E., Francis D. M., Slater N. G. The Lancet. 1992, no. 339 (8801), pp. 1078–1080.
11. Greaves M. W., Sabroe R. A. British medical journal. 1998, Vol. 316 (7138), pp. 1147–1150.
12. Jiang X., Lu M., Ying Y. et al. Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2008, no. 12 (6), pp. 505–508.
13. Hide M., Francis D.M., Grattan C.E. et al. The New England journal of medicine.1993,no.328, pp.1599–1604.
14. Molotilov B. A., Bol'ts E. A., Orlova E. A. Vestnik Ural'skoy meditsinskoy akademicheskoy nauki. Tematicheskiy vypusk po allergologii i immunologii [Bulletin of Ural medical academic science. Subject issue on allergology and immunology]. 2010, no. 2/1 (29), pp. 176–177.
15. Molotilov B. A., Orlova E. A., Bol'ts E. A. Meditsinskie nauki. Klinicheskaya meditsina [Medical sciences. Clinical medicine]. 2011, no. 4 (20), pp. 59–64.